The Infectious Diseases Biomarker group is recruiting for a Senior Scientist Respiratory Infections Biomarkers, located in South San Francisco, CA or Antwerp, Belgium.
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Janssen Research & Development discovers and develops innovative medical solutions to address unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases.
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The Infectious Diseases (ID) Therapeutic Area of Janssen R&D is pioneering new treatment paradigms with assets in late discovery and clinical development. The ID Biomarkers team develops and executes strategies to identify and implement novel biomarkers which seek to improve our understanding of the disease and of treatment efficacy, as well as safety in late discovery and early clinical trials to support clinical proof of relevance of novel treatment modalities. Effectively enable stratification of patient segments according to disease subtypes and medical need.
- In collaboration with respiratory infections discovery and early development teams, the Sr. Scientist will develop and execute on evolving biomarker plans for novel treatment assets at late stage of discovery research that will be a part of the information package that supports the transition of an asset towards early development. This individual will describe the biomarker needs in projects and propose the most appropriate technical-scientific approaches that can address these needs.
- Ensure optimal collection of samples for experimental study designs that subsequently allows application of appropriate and fit-for-purpose methods with the aim to identify relevant biomarkers from pre-clinical data and to design approaches to translate these biomarkers to clinical application in the targeted diseases.
- Responsible for the generation, analysis, interpretation and reporting of high dimensional biomarker data on samples collected in the context of discovery, translational research or early clinical studies on respiratory infectious diseases.
- Be actively engaged in participating and evaluating progress in collaborative programs with external partners on biomarker research in respiratory infection diseases aiming to develop novel insights into disease biology or prognosis and/or options for patient segmentation.
- Combine proven respiratory infections disease knowledge with data analysis and statistical expertise to characterize disease mechanisms and elucidate mode of action for novel therapeutic options.
- Drive integrative analysis and interpretation of high-dimensional biomarker data generated in the projects from a variety of platforms including next-generation sequencing, gene expression profiling, proteomics, flow cytometry, microbiome analysis and digital readouts (multisensors).
- Collaborate with other scientists from ID Biomarkers, Computational Sciences, Data Sciences, Quantitative Sciences, and R&D IT to implement data analysis approaches that address the biomarker needs for the respiratory infections discovery programs.
- Communicate and report on the scientific progress of biomarker research in the respiratory infections discovery programs.
- PhD in translational sciences or equivalent, with experience in biomarker research. Solid knowledge of immunology is required, and preferably also on infectious disease biology. At least 5 years relevant postdoctoral experience in an academic or industrial research environment required.
- Hands-on experience with multiple high-dimensional omics platforms (NGS, transcriptomics, flow cytometry, cell sorting).
- Proficiency with high-dimensional biomarker data analysis tools and software is required.
- Scientifically critical and creative mindset that identifies knowledge gaps in projects that may be related to lack of good biomarkers, and be able to propose actionable strategies that may address these gaps.
- Ability to work independently and develop new technical or data analysis skills to meet the needs of a fast-paced environment.
- Excellent communication skills, collaborative mindset and team player, willingness and flexibility to work in a highly-matrixed organization required.
What is in it for you?
- Contributing to our mission to continue to bring transformational new medicines to patients for a world without disease.
- Being part of a motivated, experienced and diverse research team in an innovative working environment
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-California-South San Francisco-
Janssen BioPharma, Inc. (6224)